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4月24日 Some gossip on E.J. Corey.Corey has gained a certain infamy in the field of chemistry for having one graduate student commit suicide and explicitly blame the advisor (Corey) for doing so. A second suicide also occurred in his lab although the student was only at Harvard for one week before doing so and was unrelated to working for Corey. The graduate student, Jason Altom, was a Ph.D. student at Harvard University who committed suicide by taking potassium cyanide in 1998, citing in his suicide note "abusive research supervisors" as one reason for taking his life. Altom was working on one of the most complex natural products and felt enormous pressure to finish the molecule before starting his academic career. Altom's suicide highlighted the plight of many Ph.D. students in similar situations(?) His case prompted many universities to insist that Ph.D. students have an advisory committee in addition to a supervisor, to whom they might turn for support: James Anderson, who became Harvard Chemistry Department Chairman, stated that "Jason's death prompted an examination of the role the department should play in graduate students' lives". Anderson went on to promise that students will also have "confidential and seamless access" to psychological counselling services, paid for by the department. However, as of 2004, this access was terminated. Corey, speaking of the suicide note, states: "[T]hat letter doesn't make sense . At the end, Jason must have been delusional or irrational in the extreme." Corey also is on record as stating that he never questioned Mr. Altom's intellectual contributions. "I did my best to guide Jason as a mountain guide would to guide someone climbing a mountain. I did my best every step of the way," Corey states. "My conscience is clear. Everything Jason did came out of our partnership. We never had the slightest disagreement." Corey's office at Harvard University is also infamous for the redlight / greenlight on the outside of the door. hehe....a-hole ☆─────────────────────────────────────☆ taxol (紫杉醇) 于 (Thu Dec 22 11:42:09 2005) 提到: 听说他做那个东西死活作不出来, 然后某位中国博士后一来2周内搞定, 可以想见corey 对这位可怜的 研究生如何另眼相看了. 他只好去自杀. 死前还留了张条提醒别人不要去给他做人工呼 吸, 以免KCN中毒 ☆─────────────────────────────────────☆ whisvender (陌上暗香，他日忘我) 于 (Thu Dec 22 11:43:43 2005) 提到: 据说之前很顺利，就是最后一步一直没做出来 ☆─────────────────────────────────────☆ taxol (紫杉醇) 于 (Thu Dec 22 11:50:27 2005) 提到: en,把两个subunit接起来失败了. ☆─────────────────────────────────────☆ liker (做啥不出啥) 于 (Thu Dec 22 12:25:32 2005) 提到: 咳,分明是HCN吗...是把KCN放在烧杯里面,然后加了一点酸... ☆─────────────────────────────────────☆ smilesun (雾迷津渡) 于 (Thu Dec 22 12:34:26 2005) 提到: 乱讲.此人巨牛的,一直是corey的baby.但太好强了.最后一不没做出来.就去死了. 后来来了一人(他死后),一步步重现他做的,还是最后一不做不出来.后来 又来一人,做出最后一步.发paper,做最后一步的第一作者,重现的第二作者, 死人没名.这就是在众教授里流行的版本.不知道对不对.但这人是在那东 东没做出来就死了的.所谓一中国postdoc两周搞定,乱讲一通.两周把人十几步的 路线走得完吗? ☆─────────────────────────────────────☆ liker (做啥不出啥) 于 (Thu Dec 22 13:00:02 2005) 提到: 版本太多,那哥们牛是一定的,好象当年已经拿到IN U的教职了...不过最后是因为重复 一步反应还是做最后那步,卡在那里,一时想不开..... ☆─────────────────────────────────────☆ ybear (阿P) 于 (Thu Dec 22 13:39:47 2005) 提到: Anyone knows what natural product is that? then We can find out how tough it is... ☆─────────────────────────────────────☆ singye (温润如玉) 于 (Thu Dec 22 13:49:15 2005) 提到: Carothers的例子早就教导我们，作为一个科研工作者，不要轻易去自杀。留得青山在不 怕没柴烧嘛。结果flory做了更多的工作，诺贝尔奖给了他。 ☆─────────────────────────────────────☆ telnet (如果我休息，祖国就不能前进) 于 (Thu Dec 22 14:22:24 2005) 提到: 一句话，看开一点，谋事在人，成事在天。 做出来是运气，做不出来，也是运气。 We are all doomed ☆─────────────────────────────────────☆ xiong (熊猫儿) 于 (Thu Dec 22 14:46:32 2005) 提到: Enantioselective Total Synthesis of Aspidophytine He, F.; Bo, Y.; Altom, J. D.; Corey, E. J. J. Am. Chem. Soc. 1999, 121(28), 6771-6772. ☆─────────────────────────────────────☆ Brevetoxin (Brevetoxin) 于 (Thu Dec 22 23:09:48 2005) 提到: 看来还真没人知道详情啊。jason altom确实是极度牛的人，就是两片接不起来。后来老 中 博士后重复了其中一片的合成，发了文章，两个博士后和自杀的加上老魔头。那个合成已 经算是遥远的绝响了。至于真正的分子至今无人能搞定，定出来结构已经30年了。据说 liker家老大在老魔头那里也试过两下，后称那个玩意根本没法作出来。我们实验室最最 牛 叉的就在做这个分子，liker家老大是其committee member，劝他毕业前最好有 publication. ☆─────────────────────────────────────☆ Brevetoxin (Brevetoxin) 于 (Thu Dec 22 23:12:12 2005) 提到: 那天fukuyama把它搞定大伙不要惊讶。 4月17日 a letter from Dave.Group, Although last week I announced that we were moving to SKI, I did not make much effort to explain to you the reason for my decision. Since you are primarily the ones responsible for the successes of the group and are all drastically affected by the decision, I think you all should know the deciding factors leading to this change. One can imagine many factors, such as pros & cons with facilities, colleagues, money, students, postdocs, living environment, etc., playing a part in this decision, and considering all these issues was essentially an impossible task. Ultimately, these factors had very little to do with my decision. The key factor was an intangible one. It was simply the excitement of taking on new challenges, accepting new risks, and the potential to reap new rewards. My job as PI is to try to push each of you to your limits, and then go a little beyond. With this decision to move, I am doing the same to myself. Our synthesis program will continue improve, and our best synthetic work is yet to come. Although we will never become pseudo-biologists, I can foresee that our chemistry will have a much greater impact on human health, with us having some of the world's best immunologists and cancer biologists just next door. Perhaps the most influential document in my decision-making process is a short autobiography of Rod MacKinnon (attached). He is Prof at Rockefeller (just across the street from MSKCC) and was the 2003 Nobel in Chemistry for his work on ion channel structure. At a time when we are hit by distractions from all directions, this inspiring story is a refreshing reminder of why we all chose to devote so much to this business -- it is all about the science. Whether circumstances allow you to relocate with me to NYC or not, I hope that the raw inspiration behind the drive to learn and discover new "things" is never lost to you. I am very excited about the future prospects.... Dave 3月3日 转载一个女孩，如果她有如下表现：殷勤回复你的每一条短信；有事情的时候总是第一个找你帮忙；对你的一举一动表现出极大的关注；喜欢向你展示她最真实的一面……你一定觉得她是无可救药地爱上你了吧？ 你误会了！这可能说明她一点也不喜欢你！ 为什么呢？原因如下： 1、假如她爱你，她应当犹犹豫豫地回复你的每一条短信。假如她不假思索地迅速回复你，只能说明她其实并不在乎她的话语会给你留下怎样的印象，她只是不想让你感觉出她的不耐烦。 2、假如她爱你，她应当在没有事情的时候来找你帮忙。她会找一些无伤大雅的问题去缠着她所喜欢的人，这样既有了接近的借口，又不会显得自己很无知。当她真的面对困惑，她会先去征求她朋友的意见，而不愿意让让喜欢的人看出她的无知与脆弱。 3、假如她爱你，她应当掩藏对你一举一动的关注。当女孩产生了爱的情感，就会同时产生羞涩的情感，她会热切地关注你的言谈举止、喜怒哀乐，同时又会羞于表达，总是欲言又止。如果她不吝惜表达对你的关注之情，那就说明她并不爱你。 4、假如她爱你，她应当像你掩饰她的缺点。男生可能更喜欢真实的女孩，可是女生却总是希望在心爱的男生面前表现出最完美的一面。许多恋爱中的女孩都会作出可爱的举动，用小鸟依人来博得男孩的欢心。如果她表现出难能可贵的爽朗、热情，显得特别的真诚，毫不矫情，那就说明她对你没意思。 2月8日 a letter from my boss.Group,
Lately, I have noticed that several (although not most) of the group are not at the bench when I go to speak with them in the mornings after 8am. The group hours policy has not changed. Please do not be late for work. I would hope that from 8am until I leave for the day, I can expect to find everyone at their bench should I need to speak with them. If you are not at your bench during this time, I would expect a clear note on the desk or bench stating if you are teaching (location), library, computer room, NMR, etc. Indeed, ALL (with no exceptions) of the labmates with whom I worked during my PhD and postdoc worked longer hours than the advisor. That was the culture, and we viewed it as the minimum time requirement in those days. Additionally, all of us worked harder when the boss was on a trip because we knew he would be very expectant of significant progress when he returned (typically in a less than optimal mood). We knew that this was worth HUGE browning points in the eyes of the advisor. Certainly, the current MTV/iPOD generation, with their entitlement nature, has gotten soft. This is the exact opposite to what I want to instill in my group graduates -- the only true entitlement is the OPPORTUNITY to work and study hard so that success can be achieved in the midst of all of the other competition in the country. If optimal advantage is taken of this situation, you will be VERY strong. After a successful PhD, you will be commanding scientists and groundbreaking scientific ideas -- this cannot be done without risk or sacrifice, let alone being able to show up for work on time. I know most of you are not among the softened MTV/iPODers of which I speak, and have always followed or exceeded the guidelines above. Don't worry -- I know who you are. Dave 这些天我都是八点多九点才到实验室，寒！！ 2月4日 this is not the end 今天老板作出一个让我吃惊的决定：cut off the internet jack, only those group computers can get access to the internet. which means I get no more web surfing, no more chinses email reading, no MSN, no ...... 老板的英明决定，出于让我们的工作更efficient的考虑，这样，即使我们有做反应的空隙，也只能读读literature, 想想chemistry. 于是， I am gonna be cut off from the normal world, what remains for me (8am-6pm, Monday through Saturday) is "CHEMISTRY". GOOD!!!!!!!
老板的另一句话更几乎让我窒息：This is no the end. This is the beginning! OK! 赞！
听说在E.J, Danishefsky, Nicolaou等等大牛的组里就是这么工作的，甚至McMillan的group一周七天的工作，no rest. Maybe that'll be the end that Dave meant?
另外：据说老板想把休息日改成周六instead of 周日。因为周日大部分地方都不营业。而周六我们可以修修车，理理发......赞again!!!
一直忘不了老板说这些话的时候那激动兴奋的表情...... |
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